Augmentation of antidepressant effects of SSRIs by GABAB antagonists: mechanistic studies
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Microdialysis approach to study serotonin outflow in mice following selective serotonin reuptake inhibitors and substance P (neurokinin 1) receptor antagonist administration: a review.
Classical antidepressant drugs such as Selective Serotonin Reuptake Inhibitors (SSRIs) display several disadvantages, e.g., the onset of action (2 to 3 weeks) to start clinical benefits is too long, and a significant proportion of patients do not respond to this monotherapy. Several strategies have been proposed to overcome these problems, notably the use of potentiating agents, which combined ...
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Objective(s): Studies indicate that major deficiency in the levels of monoaminergic transmitters is a reason for severe depression. On the other hand, it is shown that Carthamus tinctorius L. (CT) may improve neuropsychological injuries by regulation of the monoamine transporter action. Hence, the present study was undertaken to evaluate the involvement of monoaminergic systems in antidepressan...
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Cognitive and psychomotor impairment are important considerations in the treatment of depression in the elderly due to both the underlying slowing of cognitive and psychomotor processes as a normal function of aging and the superimposed deficits associated with the disease itself. Only the latter are reversible with effective antidepressant therapy. Yet certain antidepressant drugs possess seda...
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Fear can be considered as a functional defense behavior to protect living beings against dangerous situation. In our studies we have investigated the fear behavior in rats in elevated plus maze .The increase in two parameters percent of open arm entries (%OAE) and percent of time spent in the open arms (% OAT) and decrease in the percent of time spent in closed arm (%CAT) was considered as fear...
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